Important QIAGEN CLC software notifications
The QIAGEN Digital Insights Support and R&D teams are constantly reviewing support tickets and bug reports so any known issue can be handled and is fixed as soon as possible. Our aim is to ensure that QIAGEN CLC software maintains the highest possible quality to make your research faster, better and easier. Below is a list of known issues with suggested workarounds.
Issues affecting latest releases of products
Authentication of upload to QCI Interpret servers in Turkey and Japan through browser fails
IVA plugin and upload of variants following retirement of Ingenuity Variant Analysis (IVA)
Two reference insertion variants can be reported at the same position
Issues affecting only older versions of products
Local Realignment can introduce false positive insertions and deletions
QIAGEN RNA-seq Analysis Portal – miRNA expression value downloads may give wrong CPM value
Region and gene-level CNV detection problems when low coverage control targets present
Download Pathogen Database returns too few reference sequences
Transmembrane Helix Prediction always reports no transmembrane regions found
Housekeeping gene normalization is never applied by the tool Differential Expression in Two Groups
Error message appears when Primer info settings are enabled
Error message when working with custom view settings with additional restriction enzymes
Mean reference gene coverage value in QC for RNAScan Panels report is too high
Extract Reads from Selection in abundance tables not working as expected in some circumstances
Taxonomic Profiling accepts multiple host index files but uses only the first one
Taxonomic Profiling reports too few reads in low complexity samples
Import of COSMIC Release v90 is not supported
Restrictions on sequence names when creating BLAST databases
Incorrect annotation and visualization of a small minority of overlapping variants
False positives and misannotation of some fusions in fusion detection workflows
Expression values from UPX 3′ Transcriptome Kit data are systematically too high in many cases
Create MLST Scheme tool leads to strains being linked to wrong sequence type in some cases
Incorrect ARO numbers on some ResFinder entries in QMI-AR databases
Bonferroni and FDR multiple testing corrections too strict for differential expression analyses
Local realignment of certain UMI reads may differ between runs
Sporadic corruption of analysis outputs on GPFS file systems
Variants that span a target region are not called
Interquartile range test of the Detect MSI Status tool reports all loci as unstable
Some larger single deletions reported as multiple, individual deletions when affine gap scoring used
RNA-Seq Analysis does not count some reads covering start-end position of a circular chromosome
QIAseq Mitochondria Panel DHS-105Z workflow analyses use incorrect genetic code