Somatic databases for biopharmaceutical research

Developed and maintained by Wellcome Sanger Institute, the latest release, COSMIC v100 (May 2024), includes over 5 million coding mutations across 1.5 million tumor samples, curated from over 29,000 publications. In addition to coding mutations, COSMIC covers all the genetic mechanisms by which somatic mutations promote cancer, including non-coding mutations, gene fusions, copy-number variants and drug-resistance mutations.

• Integrates somatic data from multiple sources, including the International Cancer Genome Consortium, The Cancer Genome Atlas, gene- and genome-wide screens, clinical trials and therapies.
• Data is translated into a standardized format and available through downloadable datasets and user-friendly data exploration tools.
• Every six months, COSMIC content and features are updated to ensure you remain informed on the latest findings.

A relatively new somatic mutation database from QIAGEN (released in 2019), HSMD combines over two decades of expert curation and data from scientific literature, on- and off-label therapies and clinical trials, and real-world clinical oncology cases. In the latest release, HSMD 3.0 (November 2023), the database contains manually curated, detailed molecular information on over 1.8 million somatic variants, with more than 430,000 observed in real clinical cases, as well as data from over 545,000 real-world clinical oncology cases

• Contains data from clinically observed variants, meaning QIAGEN’s professional clinical interpretation service (previously N-of-One) has encountered this alteration in a real-world clinical case. 
• A searchable, web database to explore key genes or mutations with driving properties or clinical relevance and search for associated treatment options, off-label therapies, resistance markers, and regional and/or disease-specific clinical trials.
• Every three months, HSMD content and features are updated to ensure you remain informed on the latest findings.

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