Two expert-curated databases exclusively licensed through QIAGEN, the Catalogue Of Somatic Mutations In Cancer (COSMIC) and the Human Somatic Mutation Database (HSMD), provide clinical NGS testing labs with trusted data to identify and annotate biomarkers, assess their biological and clinical relevance, and support clinical trial matching and molecular tumor board (MTB) recommendations.
Comprehensive database containing over 24 million genomic variants across 6,800 precise forms of human cancer to explore the effect of somatic mutations in human cancer.
In-depth database providing detailed molecular information on over 1.8 million somatic variants to assesses the clinical and biological relevance of somatic variants across observed tumor types.
Both COSMIC and HSMD can be used to enhance the content of existing somatic NGS testing workflows. If your lab needs an end-to-end variant analysis, interpretation, and reporting workflow, learn more about QCI Interpret for Oncology here.
Developed and maintained by Wellcome Sanger Institute, the latest release, COSMIC v100 (May 2024), includes over 5 million coding mutations across 1.5 million tumor samples, curated from over 29,000 publications. In addition to coding mutations, COSMIC covers all the genetic mechanisms by which somatic mutations promote cancer, including non-coding mutations, gene fusions, copy-number variants and drug-resistance mutations.
A relatively new somatic mutation database from QIAGEN (released in 2019), HSMD combines over two decades of expert curation and data from scientific literature, on- and off-label therapies and clinical trials, and real-world clinical oncology cases. In the latest release, HSMD 3.0 (November 2023), the database contains manually curated, detailed molecular information on over 1.8 million somatic variants, with more than 430,000 observed in real clinical cases, as well as data from over 545,000 real-world clinical oncology cases.
COSMIC and HSMD are two expert-curated databases licensed exclusively through QIAGEN that enable clinical NGS testing labs to enhance the content of their informatics workflow.
To learn more about how your bioinformatics and variant scientist team can use COSMIC and HSMD, click the button below for a free trial and personal consultation with our clinical NGS testing experts.
