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Catalogue of Somatic Mutations in Cancer (COSMIC)

A trusted resource to better understand somatic cancer mutations

The world's largest, expert-curated somatic mutation database

COSMIC

COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world’s largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Containing nearly 24 million genomic variants across nearly 6,800 precise forms of human cancer, COSMIC provides variant scientists and bioinformaticians with an expert-curated database to:

  • Prioritize clinically relevant variants
  • Annotate variants with actionability
  • Rapidly assess somatic frequency
  • Precisely map genomic coordinates
  • Contextualize reports with COSMIC IDs

Learn how to predict and avoid mutational consequences of cancer therapies with COSMIC

On March 7, join our live webinar with Dr. Kyle Nilson to learn how the Catalogue Of Somatic Mutations In Cancer (COSMIC) can be used to avoid mutational consequences in cancer drug development and to profile the mutational signatures of cancer therapies in clinical samples. The session will be followed by a Q&A session with COSMIC curator Steven Jupe.

Features

COSMIC Actionability

A resource that addresses the question “What treatment options are available or under investigation for cancer patients with somatic mutations?”

COSMIC Actionability delivers the latest data on the availability and development of drugs targeting specific somatic mutations in cancer.

Actionability covers clinically relevant mutations and alteration types in relevant genes for some of the most frequently sequenced cancer types such as lung, breast, melanoma, ovarian, and colon cancer.

High Precision, Manual Curation

COSMIC deploys high precision manual curation methods by PhD-level experts with decades of experience.

The primary data in COSMIC are derived directly from the scientific literature by expert manual curators, who read and digest journal articles and extract detailed mutation data, along with additional information such as environmental factors or patient pre-disposition that may be accessible.

A second curation track brings into COSMIC a wealth of larger-scale but more narrowly-focussed data from systematic screens, via the major cancer data portals and from the supplementary tables and downloadable files associated with curated papers.

Exponential Increase in Mutations

Over the last five releases, COSMIC has increased the number of genomic mutations by over 17%.

Every four months, COSMIC content and features are updated to ensure you remain informed on the latest findings.

In the last five releases, over 3.4 million new mutations, over 93,000 new samples, and over 1,700 new articles were added.

Genome-wide Annotation

COSMIC provides genome wide annotation with over 23 million genomic variants across 6,800 precise cancer types.

COSMIC encompasses every human gene, describing 5,037,981 coding mutations across 1,515,965 samples.

Key cancer genes are subject to deep, exhaustive curation by expert scientists. This is merged with genome-wide annotations from 41,161 whole genome and large-scale systematic screens publications, as well as open-access data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC).

Transparent Evidence Citations

In COSMIC, every data point is traceable to the source, data processing is documented, and the user has full control over all the data.

The primary data in COSMIC are derived directly from the scientific literature by expert manual curators, who read and digest journal articles and extract detailed mutation data, along with additional information such as environmental factors or patient pre-disposition that may be accessible.

A second curation track brings into COSMIC a wealth of larger-scale but more narrowly-focussed data from systematic screens, via the major cancer data portals and from the supplementary tables and downloadable files associated with curated papers.

Easy Search Functionality

With COSMIC, you can search for Disease, Gene, Variant, Sample, or Study with all data derived directly from a cited source.

COSMIC is designed to provide ease-of-use and maximum flexibility. Users have full control of how they search the data, visualize the data, and manipulate the data for specific panels and/or pipelines.

You can integrate the complete raw dataset into your lab’s proprietary database.

Use-Cases

How to search by gene, cancer type, and mutation Here, we show you how to search COSMIC for a gene, cancer type, and mutation using BRAF as an example.

The world's largest, expert-curated somatic mutation database

+23M
Total Genomic Variants
+1.5M
Total Human Samples
+29,000
Expert-curated Papers
+50,000
Users Worldwide
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Resources

Events & Webinars

Learn how to predict and avoid mutational consequences of cancer therapies with COSMIC

On March 7, join our live webinar with Dr. Kyle Nilson to learn how the Catalogue Of Somatic Mutations In Cancer (COSMIC) can be used to avoid mutational consequences in cancer drug development and to profile the mutational signatures of cancer therapies in clinical samples. The session will be followed by a Q&A session with COSMIC curator Steven Jupe.

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