QIAGEN PGXI

QIAGEN Pharmacogenomic Insights

A new pharmacogenomics knowledgebase for scientific and translational researchers to rapidly generate genomic and therapeutic insights to optimize drug development and delivery

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Decode drug response to variation in the genome

Each year, more than 134 million patients experience adverse drug events,
causing 2.4 million deaths worldwide (1).

What if there was a better way to develop and prescribe safer, more effective drugs based on the unique genetic information of every individual?

QIAGEN Pharmacogenomic Insights (PGXI)

For labs and pharmaceutical companies needing an easier and faster way to translate complex pharmacogenomic data into evidence-backed insights to inform drug delivery and development, QIAGEN PGXI provides a better a way forward.

What is it?

An expert-curated pharmacogenomic knowledgebase providing comprehensive access to verified and up-to-date evidence on gene-drug associations to personalize drug therapies.

EXPERT-CURATED CONTENT

How does it work?

A PGx knowledgebase where scientific and translational researchers retrieve insights into gene-drug associations, conditions, and curated literature evidence for submitted inputs.

AUTOMATED PGX ANNOTATION

What's the value?

Unlike manual or semi-automated approaches to PGx annotation that can take hours or days, QIAGEN PGXI reduces turnaround time to minutes and eliminates the high cost of maintaining bioinformatic and technical support.

EASIER, FASTER, SCALABLE

A better way to interpret genetic data in relation to drug response

PGXI is a new PGx knowledgebase solution built upon a legacy platform used to deliver more than 1.6 million PGx annotations for more than 250 clinical research laboratories.

A proven solution that enables labs and pharmaceutical companies to efficiently and confidently produce evidence-backed insights for PGx markers and better understand implications for relevant medications, PGXI easily integrates into existing or new workflows to provide automated annotation of PGx data from all platforms, including NGS and arrays. Within minutes, users can retrieve a custom output of relevant information, including:

  • Relevant conditions associated with queried genes of interest;
  • Relevant drug-gene associations;
  • Curated literature evidence for alleles in question.

A deeply researched knowledgebase with advanced annotation capabilities

Unlike other solutions, PGXI provides access to an expert-curated knowledge base leveraging verified evidence from a variety of sources. Eliminating the need to consult multiple databases, PGXI is updated quarterly to ensure you have the most accurate, comprehensive, and up-to-date information in one central location.

PGXI contains expert-curated and -verified data from all established PGx information sources, including: 

  • FDA 
  • CPIC
  • DPWG 
  • PharmVar
  • Curated information from PubMed 

PGXI provides automated annotation of PGx results. The solution:

  • Contains robust capabilities to call star-alleles for results to infer the clinical phenotypes.
  • Assigns haplotypes and gene diplotype
  • Enables phenotype mapping based on consensus guidelines
  • Provides PGx insights
  • Delivers standardized outputs that can be integrated into internal systems

Technology-agnostic, PGXI integrates seamlessly into your internal pipelines and workflows, allowing you to leverage cutting-edge pharmacogenomic content without disrupting your processes.

You access the data how you need it – whether through an application programming interface (API), flat files, or as data slices as a service.

How does it work?

PGXI is an agnostic database solution that can be integrated into existing and new PGx workflows. The below graphic provides a sample workflow.

Reduce costs and turnaround time

Rapidly query and identify associations linked to genotypes

By automating the identification of associations linked with genotypes, PGXI enables labs and pharmaceutical companies to efficiently and consistently identify medications associated with adverse effects.

Deliver trusted insights

The most comprehensive pharmacogenomics content in the industry 

PGXI leverages over a decade of experience in manually curating consolidated content from standard PGx sources, such as the FDA, CPIC, DPWG, PharmVar, PubMed, and more. 

With the ability to rapidly assess PGx variants with expert-verified, quality content, labs and pharmaceutical companies can deliver trusted insights that can help improve outcomes and minimize overall health burdens.

Seamlessly scale your PGx workflows

Technology-agnostic integration with flexible access to comprehensive PGx content

PGXI is a technology-agnostic knowledgebase that ensures compatibility and flexibility across diverse platforms, including NGS and arrays. 

Organizations can integrate and transition between different technologies and platforms without disruption, protecting their investments in existing infrastructure.

"By adding PGXI to our industry-leading portfolio of expert-curated databases, we are streamlining and accelerating this critical process by offering a single, authoritative source of information, verified and continuously updated, allowing users to make informed decisions with confidence.”

Dominic John, PhD
Head of QIAGEN Digital Insights

Try QIAGEN Pharmacogenomic Insights (PGXI) today

For labs and pharmaceutical companies, there is an easier and faster way to translate pharmacogenomic data into insights.

Discover how PGXI can transform your PGx program.

Disclaimer: PGXI is a knowledgebase subsystem designed for integration into broader workflows or systems and is not intended as a standalone finished product for direct clinical use.

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References:

1. Kamath A, Acharya SD, Poovizhi Bharathi R. Burden of death and disability due to adverse effects of medical treatment in India: An analysis using the global burden of disease 2019 study data. Heliyon. 2024;10(2):e24924-e24924. doi: https://doi.org/10.1016/j.heliyon.2024.e24924

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