QIAGEN CLC Workbench Features

Explore some of the popular features of our Main and Genomics Premium workbenches.

QIAGEN CLC Main Workbench

Access sequence analysis tools and more with our original workhorse platform. All listed features are also available in CLC Genomics Workbench Premium, our NGS analysis solution.

Sanger sequencing data analysis

Import Sanger sequencing data (.SCF, .ABI, .PHD) and map them to a reference sequence or assemble them into contigs. Identify and inspect called variants and inconsistencies, and visualize traces, trimmed ends, coverage and more for each contig.

  • Detect heterozygous mutations with chromatograms
  • Trim sequence reads with quality scores, ambiguity characters and vector contamination
  • Conduct analyses like BLAST analysis or cloning experiments
Primer design

Design oligonucleotides (primers) with adjustable criteria and dynamically updating calculations. Create your own standard and nested PCR primers, TaqMan probes and sequencing primers based on multiple sequence alignments.

Cloning

Vector design and analysis tools are available for different types of cloning, including in silico, in silico homology-based (Gibson), restriction and Gateway (single- and multi-site).

Expression analysis

Analyze expression data produced on microarray platforms and perform quality control, transformation, normalization and statistical analyses to measure differential expression.

Phylogenies

Create phylogenetic trees and add associated metadata with K-mer-based tree construction. Test models to find the best statistical approaches and visualize imported metadata on tree topology.

Workflows

Build your own custom workflows, moving data effortlessly through any sequence of tools and standardizing sample analysis. Workflows can be used locally, on servers or sent to colleagues.

3D protein structure viewer

Customize the visualization of your molecules or use our premade styles. View annotations and variants in their structural context with synchronized views for proteins and nucleic acids.

Alignment

All Workbenches include pairwise and multiple sequence alignments of DNA, RNA and protein sequences, including ClustalW and Muscle. With Whole Genome Alignment, you can investigate dot plots, multiple genome alignments, average nucleotide identities and more.

  • Join alignments and construct “supergenes” for phylogenetic inference
  • Transfer annotations between sequences in alignments
  • Extract multiple sequence alignments and consensus sequences for further analyses
Provenance

Export the timestamped history of every data element as a PDF or txt/JSON file. Metadata includes data origin, author, workflow and algorithm version names, parameters and other values set.

Get specialized analysis features

Don’t see what you want? Customize your CLC Workbench for your specific analysis needs.
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QIAGEN CLC Genomics Workbench Premium

Our all-in-one bioinformatics software solution expands the Main Workbench into NGS analysis. Analyze your genomics, transcriptomics and metagenomics data with user-friendly workflows and extract insights from long and short read NGS data.

Genome analysis

Fast, efficient de novo assembly, including trimming tools to remove low-quality data, and support for Sanger sequencing, short and long read NGS data and hybrid assemblies.

  • De-novo assembly and genome finishing
  • Whole genome alignment
  • Gene finding and annotation
  • Bisulfite sequencing
  • ChIP-seq analysis for transcription factors and histones
Transcriptomics

Easy-to-use workflows that cover the entire analysis process and accommodate any experimental design. All tools account for sequencing depth differences, removing the need to normalize input data.

  • RNA-seq analysis
  • Differential expression analysis
  • Transcript discovery
  • Single-cell analysis
Resequencing

Start detecting and comparing genetic variants, including low-frequency, single- and multi-nucleotide, copy number and other large structural variants, insertions, deletions and replacements.

  • Ultra-fast read mapping and comprehensive variant detection, including structural variants, copy number changes and loss-of-heterozygosity regions
  • Support for targeted amplicon panels, hybrid capture and WGS
  • Consensus sequence creation
  • Oncology scoring tools for TMB, MSI and HRD
  • Viral integration site detection
Microbiome metagenomics and metatranscriptomics

Explore outbreaks, antimicrobial resistance and more.

  • Microbiome analysis (OTU and ASV)
  • Taxonomic profiling
  • Metagenomic binning and assembly tools
  • Functional annotation and pathway analysis
  • Microbial outbreak analysis, including AMR and virulence typing, MLST support and SNP, k-mer and minimum spanning trees
Sample to Insight
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