COSMIC Actionability delivers the latest data on the availability and development of drugs targeting specific somatic mutations in cancer.

Actionability covers clinically relevant mutations and alteration types in relevant genes for some of the most frequently sequenced cancer types such as lung, breast, melanoma, ovarian, and colon cancer.

The primary data in COSMIC are derived directly from the scientific literature by expert manual curators, who read and digest journal articles and extract detailed mutation data, along with additional information such as environmental factors or patient pre-disposition that may be accessible.

A second curation track brings into COSMIC a wealth of larger-scale but more narrowly-focussed data from systematic screens, via the major cancer data portals and from the supplementary tables and downloadable files associated with curated papers.

Every four months, COSMIC content and features are updated to ensure you remain informed on the latest findings.


In the last five releases, over 3.4 million new mutations, over 93,000 new samples, and over 1,700 new articles were added.

COSMIC encompasses every human gene, describing 5,037,981 coding mutations across 1,515,965 samples.

Key cancer genes are subject to deep, exhaustive curation by expert scientists. This is merged with genome-wide annotations from 41,161 whole genome and large-scale systematic screens publications, as well as open-access data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC).

The primary data in COSMIC are derived directly from the scientific literature by expert manual curators, who read and digest journal articles and extract detailed mutation data, along with additional information such as environmental factors or patient pre-disposition that may be accessible.

A second curation track brings into COSMIC a wealth of larger-scale but more narrowly-focussed data from systematic screens, via the major cancer data portals and from the supplementary tables and downloadable files associated with curated papers.

COSMIC is designed to provide ease-of-use and maximum flexibility. Users have full control of how they search the data, visualize the data, and manipulate the data for specific panels and/or pipelines.

You can integrate the complete raw dataset into your lab’s proprietary database.