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Using COSMIC to predict, identify, and avoid mutational consequences of cancer therapies during early drug development and in patients

Details

Date:
March 7, 2024
Time:
11:00 am - 12:00 pm
Website:
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Venue

  • Virtual - Americas - EST
  • United States

March 7, 2024 @ 11:00 am - 12:00 pm

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Whether your lab is researching and developing targeted cancer therapies or you are analyzing and interpreting diagnostic tests at the point-of-care, a critical part of your workflow is understanding the structural and functional impact of cancer-related mutations.

The Catalogue Of Somatic Mutations In Cancer (COSMIC) is an expert-curated database encompassing a wide variety of somatic mutation mechanisms causing human cancer. Containing more than 24 million somatic variants with detailed information on mutation distribution, effects, and signatures, COSMIC helps users better predict the cancer-driving effects of mutations and identify available drugs that target specific variants. COSMIC continues to expand its utility with continuous updates to its Mutational Signatures, the Cancer Mutation Census, and Mutation Actionability in Precision Oncology products.

To illustrate key applications of these features, this webinar will focus on how COSMIC can be used to avoid mutational consequences in cancer drug development and to detect mutational consequences of therapies in clinical diagnostics.

Through these clinical and discovery use cases, attendees will:

  • Learn how to use COSMIC to identify and prioritize coding and non-coding mutational hotspots
  • Understand how COSMIC helps determine actionability of clinically approved homologous recombination deficiency signatures
  • Explore future uses of non-coding and signature-based COSMIC content for drug development and potential clinical diagnostic applications

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