We are pleased to announce the availability of a new release for COSMIC, the Catalogue of Somatic Mutations in Cancer. COSMIC Actionability v13 adds new actionability data to the world’s largest, expert-curated somatic mutation database. The release includes over 430 new clinical trials, 50 new therapies, 195 new therapy combinations, and detailed information on 9 new fully curated somatic genes with clinical significance.
In this article, we provide a summary of the COSMIC Actionability v13 release highlights.
COSMIC is an expert-curated database encompassing the wide variety of somatic mutation mechanisms causing human cancer. Owned and maintained by the Wellcome Sanger Institute, COSMIC is exclusively licensed through QIAGEN.
COSMIC’s team of variant scientists manually curates key cancer genes to provide in-depth information on mutation distributions and effects. The team relies on a semi-automated curation process of cancer genomes to provide broad somatic annotations toward target discovery and identification of patterns and signatures. To date, COSMIC contains over 24 million somatic mutations associated with more than 6,800 human cancers.
COSMIC Actionability is a standalone product within the COSMIC database that provides information on the availability and development of drugs targeting somatic mutations in cancer. COSMIC’s certified curation team integrates data from case studies, clinical trials, and regulatory bodies to represent a full picture of the current precision oncology pipeline (from drug development, through safety and clinical phases, to market and repurposing).
Actionability contains information on three core units: mutations, diseases and drugs. By capturing relations between these units, COSMIC’s team identifies existing and upcoming drugs that target specific genetic variants in different cancer types.
Releases of Actionability occur more frequently than COSMIC to better reflect the rapid pace of global precision oncology. Actionability is a cutting-edge, ‘living-tool’ that ensures you always have the latest, expert-certified data to inform therapeutic decision-making.
→ View the full COSMIC Actionability v13 Release Notes here.
Explore the industry-leading somatic mutation database and request free COSMIC sample data by clicking the link below. For more information on applications and case studies, check out our featured resources.
