{"id":12203,"date":"2016-10-07T09:48:32","date_gmt":"2016-10-07T09:48:32","guid":{"rendered":"https:\/\/staging.digitalinsights.supremeclients.com\/?p=12203"},"modified":"2020-04-28T11:39:21","modified_gmt":"2020-04-28T11:39:21","slug":"low-frequency-variant-detection-with-increased-accuracy","status":"publish","type":"post","link":"https:\/\/staging.digitalinsights.supremeclients.com\/news\/blog\/clinical\/low-frequency-variant-detection-with-increased-accuracy\/","title":{"rendered":"Low frequency variant detection with increased accuracy"},"content":{"rendered":"

Using new QIAseq DNA Targeted Panels with Biomedical Genomics Workbench increases the accuracy of detecting low frequency variants.<\/h4>\n

We are excited to launch the QIAseq DNA V3 Panel Analysis<\/a> plug-in for Biomedical Genomics Workbench<\/a> and Biomedical Genomics Server Solution<\/a>. The plug-in analyzes and visualizes data from the new QIAseq Targeted DNA Panels \u2014 as well as custom DNA panels designed via the Custom Panel Design Service. When combined with Biomedical Genomics Workbench, the QIAseq Targeted DNA Panels enable \u2018Digital NGS\u2019 with high accuracy for detecting low frequency variants.<\/p>\n

\u2018Digital NGS\u2019 offers a unique approach, which incorporates unique molecular indices (UMIs)\u00a0into the starting DNA material before any amplification takes place. This process eliminates errors due to PCR duplicates, which can lead to false positives, false negatives, and an altered allelic fraction\/allele frequency of detected variants. By labeling each biomolecule with a UMI, the software is able to filter out PCR artifacts, which increases overall sensitivity and specificity in detecting low frequency variants. In addition, ligation artifacts are automatically removed.<\/p>\n

The new QIAseq DNA V3 Panel Analysis plug-in provides a complete, ready-to-use workflow with all necessary analysis tools and many optimized, locked down parameter settings for analyzing Illumina data \u2014 making it simple to analyze your UMI-based panel data with Biomedical Genomics Workbench, with no expert bioinformatics expertise needed.<\/p>\n","protected":false},"excerpt":{"rendered":"Using new QIAseq DNA Targeted Panels with Biomedical Genomics Workbench increases the accuracy of detecting low frequency variants. We are…","protected":false},"author":18,"featured_media":12561,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4],"tags":[84,14,346,345,336],"class_list":["post-12203","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical","tag-biomedical-genomics-server-solution","tag-biomedical-genomics-workbench","tag-digital-dna-sequencing","tag-qiaseq-dna-v3-panel","tag-qiaseq-targeted-dna-panels"],"acf":[],"yoast_head":"\nLow frequency variant detection with increased accuracy - Bioinformatics Software | QIAGEN Digital Insights<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Low frequency variant detection with increased accuracy - Bioinformatics Software | QIAGEN Digital Insights\" \/>\n<meta property=\"og:description\" content=\"Using new QIAseq DNA Targeted Panels with Biomedical Genomics Workbench increases the accuracy of detecting low frequency variants. 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