Bioinformatics Software | QIAGEN Digital Insights

Shed light on inherited mutations and solve hereditary investigations with QCI Interpret
2023-04-19 11:00 - 12:00 UTC
In this webinar, we will demonstrate how QCI Interpret can improve your diagnostic yield for hereditary disorders. QCI Interpret is a clinical decision support platform that leverages augmented molecular intelligence to streamline the interpretation workflow. It uses the most extensive, globally trusted and manually curated molecular knowledge and bibliography evidence to provide you with the best possible opportunity to solve every case. By demonstrating the different features and series of use-cases, we will show you how QCI Interpret guarantees a comprehensive and thorough investigation of every case for all types of genetic variation, including copy number variants (CNVs). This will allow you to provide precise answers to patients and their families, while also reducing test turnaround time from hours to minutes.
Learning objectives:

Learn about QCI Interpret’s analysis and interpretation workflow for hereditary diseases using targeted and extended gene panels, including WES/WGS
Learn about QCI Interpret and QIAGEN’s expert curation process based on the latest ACMG carrier screening guidelines
View demonstrations of unique features in QCI Interpret, including how to input symptoms relevant to a case and receive relationships to candidate diseases and mutated genes using the Phenotype Network Analysis feature and triage mode of variant assessment.
Learn how QCI Interpret supports CNV interpretation and reporting with bibliographic coverage of over 60,000 CNV case reports"

Public single-cell RNA-seq data investigation using QIAGEN OmicSoft and Ingenuity Pathway Analysis
2023-04-18 13:00 - 14:30 UTC | Virtual - Americas - EST, United States
Single-cell RNA-sequencing (scRNA-seq) is widely used to investigate tissue heterogeneity, identify novel cell types, study pathogenic mechanisms, develop targeted therapy (including immunotherapy) and more. Accordingly, a tremendous amount of scRNA-seq data has been deposited to public domains like GEO.
In this training, you will learn how to
· Locate public single-cell studies of interest using QIAGEN Omicsoft Single Cell Lands
· Study different cell types by dimension reduction plots (for example, t-SNE, UMAP)
· Investigate expression of genes of interest across different cell types (Violin plots, overlay expression on cluster)
· Identify key pathways and regulators from scRNA-seq data using QIAGEN Ingenuity Pathway Analysis (IPA)

Make discoveries from public data (GEO, SRA and more) using QIAGEN Ingenuity Pathway Analysis
2023-04-13 13:00 - 14:30 UTC | Virtual - Americas - EST, United States
You asked for it, and we’re here to deliver. We are hosting a comprehensive training on effectively using sample-level public data and metadata from sources like GEO, SRA, TCGA, GTEx, Blueprint, CCLE and others through QIAGEN Ingenuity Pathway Analysis (IPA) and the IPA Analysis Match Explorer feature. We’ll walk you through use cases involving biomarker discovery, drug target investigation, studying survival in custom patient cohorts, multi-gene correlation and more.
We’ll cover topics like:
• How is a gene of interest expressed across different conditions?(‘conditions’ refers to diseases, disease subtypes, treatments, cell types, cell lines and more)
• Is there a correlation in expression for two genes or biomarkers of user interest for a given condition?
• Can we compare more than two genes in a heatmap?
• For a given condition of interest, can we derive a list of genes (for example, genes specific to a disease, treatment or cell type)?
• Can we generate custom cohorts of patients (for example, TP53 wt vs. mutant or PDCD1 high vs. low expression) and then create survival curves representing those cohorts? Can we generate a p-value to see if there is a significant difference?
• Can we detect the expression of a gene in different cell types from single-cell data?

Take your genome research to the next level with QCI Interpret Translational
2023-04-13 11:00 - 12:00 UTC
Learn how QCI Interpret Translational can get your research to the next level by providing you all the necessary analysis tools with the world’s most comprehensive and up-to-date curated scientific evidence. Get valuable and reliable insights for your research project and speed up your discoveries by using a streamlined NGS analysis workflow in a user-friendly interface without needing bioinformatics expertise.
In this webinar, attendees will have the opportunity to:

Explore capabilities which can enable them to accelerate discoveries from hereditary or tumor cohort analyses
Discover interactive tools with current and comprehensive associations between gene variants and diseases
Learn how these resources are supported by unique curated content among other integrated scientific evidence

Pathogen detection in wastewater samples using QIAGEN CLC Genomics Workbench
2023-04-11 13:00 - 14:30 UTC | Virtual - Americas - EST, United States
In this 90-minute training, you will learn how to easily analyze wastewater samples to detect pathogens (SARS-COV2, etc.) using QIAGEN CLC Genomics Workbench software.
You will learn how to:
• Importing reads
• Open and modify prebuilt workflow (analysis pipeline)
• Install and execute workflow
• Review QC reports
• Perform genome visualization
• Export the consensus sequence in FASTA format to upload to Pangolin
• Create a SNP tree of the consensus sequence and overlay Pangolin information
• Export graphical and tabular results

Can you trust AI for germline variant curation? A Stanford University case study
2023-04-05 11:00 - 12:00 UTC
In this webinar, we examine a new study by Stanford University that analyzes the accuracy, consistency, and comprehensiveness of automated and manual germline variant curation. The study compares the quality of data from Stanford’s Automatic VAriant evidence DAtabase (AVADA) to the Human Gene Mutation Database (HGMD), an expert-curated resource for human inherited disease mutations.
By attending this webinar, you will:

Analyze a series of use-cases comparing the performance of AI-driven variant curation to manual approaches
Receive a virtual demonstration of how HGMD presents mutation data, including how the database provides genomic coordinates, Human Genome Variation Society (HGVS) nomenclatures for variants, citations from key publications, and where a variant is described in a paper or supplemental text
Learn how HGMD simplifies literature review and supports CNV interpretation
Receive a complimentary 5-day trial of HGMD Professional

New user training: Large dataset analysis and knowledge base queries using QIAGEN Ingenuity Pathway Analysis (IPA)
2023-04-04 13:00 - 14:30 (America/New_York) | Virtual - Americas - EST, United States
Join us for a 90-minute training session for new users of QIAGEN IPA.
In this training, you’ll learn how to:
• Upload your dataset (RNA-seq, scRNA-seq, proteomics, metabolomics and more) and perform interactive core/pathway analysis in IPA
• Understand the different result types produced (pathways, key regulators, impact on biological functions/diseases and more)
• Compare different experimental conditions (treatments, time points, single-cell clusters, disease types and more) and identify similarities and contrasts
• Generate a network even without a dataset or experimental design for hypothesis generation
For those with IPA license,
To install IPA before or after this training, please use below installer.
https://qiagen.showpad.com/share/CBv30blCPKFDUYHRWtAvI

Accéder rapidement à une connaissance exhaustive pour l’interprétation des variants somatiques avec HSMD
2023-03-30 10:00 - 11:00 UTC
L’interprétation et la classification des variants somatiques demeurent un challenge alors que le nombre de gènes testés continue d’augmenter faisant apparaitre de nouvelles altérations. Ces nouveaux variants dont l’impact clinique est encore inconnu nécessitent une recherche d’information croisée à partir de nombreuses sources. Déterminer la classification d’un variant peut donc s’avérer longue et fastidieuse. La base de variants somatiques HSMD est une ressource en ligne qui vous permet rapidement et en toute confiance de classer vos nouveaux variants. En effet, HSMD contient plus de 300 000 cas en oncologie clinique et plus de 1,5 millions de mutations et leurs données associées, manuellement capturées et intégrées dans la base de connaissance QIAGEN. Le profil mutationnel de gènes d’intérêt, les gènes fréquemment mutés dans une pathologie donnée, l’actionnabilité d’un gène ou encore les essais cliniques pour un cancer ou un traitement spécifique sont des requêtes que les utilisateurs d’HSMD peuvent effectuer simplement. Vous découvrirez lors de ce webinaire comment utiliser HSMD pour votre routine clinique ou dans un cadre de recherche translationnelle.

Multi-omics (metabolomics, proteomics, transcriptomics) analysis using QIAGEN Ingenuity Pathway Analysis
2023-03-23 13:00 - 14:30 (America/New_York) | Virtual - Americas - EST, United States
This 90-minute training session is about how QIAGEN Ingenuity Pathway Analysis (IPA) allows visualization of molecular intricacy and variations at multiple levels such as transcriptome, proteome, and metabolome. Through a series of brief technical vignettes, it is demonstrated how to:
· Generate associations among molecular signatures obtained via integrating multi-omics data
· Extract mechanisms from multi-omics data for precision medicine
· Disease stratification based on multi-omics profiles
· Map disease networks among targets and indications

Click here to register.

How to simplify somatic NGS analysis & reduce literature review time by 90% with HSMD
2023-03-23 11:00 - 12:00 (America/New_York) | Virtual - Americas - EST, United States
Across clinical oncology applications, from molecular testing to cancer research, the ability to identify potentially actionable genomic and genetic alterations to exploit the molecular vulnerabilities of cancer is a burgeoning field. Due to the sporadic nature of somatic cancers and the expansion of next-generation sequencing, the number of variants detected through tumor testing is growing exponentially, presenting a challenge to clinical cancer genetics professionals working to confidently identify meaningful mutations that could influence decision-making at point-of-care.

Join Chelsea Alexander, a certified genetic counselor, and Aarthi Goverdhan, our lead oncology application development scientist, for a live webinar on Thursday, March 23rd at 11 AM EST to discover a new database that can streamline your somatic NGS analysis and significantly reduce your literature review time—by up to 90%!

In this webinar, we will introduce you to the Human Somatic Mutation Database (HSMD)—a new somatic database developed by QIAGEN that contains extensive genomic content relevant to solid tumors and hematological malignancies. Available as a web-based application, this expert-curated resource contains data from over 419,000 real-world clinical oncology cases combined with insights from the QIAGEN Knowledge Base, providing clinically observed variant frequencies across diseases, and diving deep into gene-level, alteration-level and disease-level information. Users can easily search and explore mutational characteristics across genes, synthesize key findings from drug labels and professional guidelines, explore clinical trials, and receive detailed annotations for each observed variant. In addition, users can interrogate a bibliography of over 170,000 PubMed articles and access detailed alteration-specific summaries written by PhD scientists.

Lowering NGS analysis cost at lightspeed
2023-03-22 12:00 - 13:00 UTC | Virtual - Americas - EST, United States
Advances in next-generation sequencing (NGS) technologies over the years have significantly decreased the cost of whole genome (WGS) and whole exome (WES) applications, such that they are considered the standard of care within multiple healthcare organizations. Arguably, the most significant NGS challenges lie within data analysis and interpretation. Various parameters such as sensitivity, specificity, cost and speed are critical for secondary analysis, while accurate, comprehensive and up-to-date content is required for reliable interpretation. These aspects are crucial, especially where rapid turnaround times are critical for improved health outcomes. There is no better example than the implementation of WES and WGS in the neonatal and pediatric intensive care units (NICU/PICU).
Join this webinar to learn about QIAGEN CLC LightSpeed, a secondary analysis software that dramatically reduces the cost and time it takes to analyze WES and WGS data and generate actionable insights.
Key learning objectives

Learn how to process FASTQ files to obtain quality variant calls in minutes
Discover how LightSpeed can be used on existing laptops, desktops, servers, HPC or in the cloud
Learn how LightSpeed will reduce your cost without sacrificing quality
Explore how LightSpeed enables the fastest WES and WGS workflow from FASTQ to report

Who should attend?
Bioinformaticians, Geneticists, Lab managers, NGS technicians, researchers, and biologists

IPA deeper dive: Generating novel discoveries in IPA - even when you don’t have data
2023-03-16 13:00 - 14:30 (America/New_York) | Virtual - Americas - EST, United States
Take a deeper dive into the discovery capabilities of QIAGEN IPA. In this training, you will learn how to:
• Leverage the IPA knowledge base to generate hypotheses regarding novel biological mechanisms, discover biomarkers and targets as well as design experiments.
• Generate interactive networks using genes, chemicals and diseases of interest
• Search and interpret pathway analyses generated from public data (GEO, SRA etc.)
• Study gene or biomarker expression across different tissues, diseases, cell types and more from public sources
• Correlate expression of genes across your biological condition of interest
• Generate survival curves for cohorts generated based on expression or mutation status of a gene
Specific IPA analyses to be featured include:
• Network construction (with and without data) • Activity Plot • Pattern Search • QIAGEN OmicSoft Land Explorer • Among others

Biomarker discovery and disease pathology investigation using QIAGEN OmicSoft and Ingenuity Pathway Analysis
2023-03-14 13:00 - 14:30 UTC | Virtual - Americas - EST, United States
In this training, attendees will learn how to harness curated ‘omics datasets in OmicSoft DiseaseLand and curated research findings in IPA to discover new potential biomarkers. Using a neurological disorder as a case study, we will:
• Search public RNA-Seq datasets for tissue- and disease-specific differential expression in brain
• Identify genes whose expression correlates with our factor within a sample group
• Prioritize candidate biomarkers by disease vs. normal expression
• Simulate biomarker activity changes to determine potential mechanisms of action
Investigation of inflammatory, infectious, oncological, and other disorders can also be done using similar approach and will be highlighted during this training.

Click here to register.

Authenticated and reproducible cell line 'omics data
2023-03-12 00:00 - 23:59 UTC | Virtual - Americas - EST, United States
Have you ever tried to access the genomic profiles of cell lines before using them in your preclinical experiments just to come up empty-handed? Maybe you’ve scoured public databases for gene expression information on your cell line to find the reported genomic profile doesn't match the cell line data you recently purchased?
We understand that knowing the genomic identity of your cell lines is fundamental to the success of your preclinical experiments. Unfortunately, most publicly available sources have little or no cell line' omics data, leaving you to fend for yourself.
That's why we've teamed up with ATCC, the market leader in global biological materials and authenticated cell lines, to deliver you manually curated cell line ‘omics data from the most popular cell lines offered by ATCC. We've collected this data into ATCC Cell Line Land, our continually growing database of cell line 'omics data from both common and novel human and mouse cell lines, primary tissues and cells from ATCC. ATCC Cell Line Land gives you access to standardized, authenticated and reproducible cell line 'omics data characterizations which can be traced back to physical lots of cells in ATCC's biorepository.
Attend our joint webinar with ATCC to learn about and explore ATCC Cell Line Land, including:

The key limitations of public cell line data that drove its development
How we curate our data in the QIAGEN OmicSoft Lands framework
Why you can depend on the provenance of the data
The different types of 'omics data and metadata available
How it empowers you to plan and design your preclinical experiments more precisely
How to identify specific cell lines that express your gene of interest and those that don't
How to validate specific mutations from the literature

Who should attend? Biologists, preclinical researchers, bioinformaticians, data scientists
Click here to register.

Isolate Typing, Strain Identification and Anti-Microbial Resistance Analyses Using QIAGEN CLC Genomics Workbench
2023-03-09 13:00 - 14:30 (America/New_York) | Virtual - Americas - EST, United States
QIAGEN CLC Genomics Workbench provides tools and workflows for a broad range of bioinformatics applications, including microbiome analysis, isolate characterization through SNP and K-mer trees using NGS data, and antimicrobial resistance characterization. CLC Genomics Workbench is widely used for analyses of bacterial, viral and eukaryotic (fungal) genomes and metagenomes.
Topics covered in this webinar include:
I. Overview of different tools within MGM application and research areas supported
II. Focused review of isolate typing and characterization
a. Importing data
b. Utilization of metadata
c. Downloading and managing references
i. Database of Isolates/ Resistances/ MLST
d. Walk through of Type a Known Species workflow
i. Review details for each Isolate
e. Creating SNP profiles to specific reference
f. Generate a SNP tree for isolate comparison
g. Export tabular and high-quality graphical outputs in wide range of file formats

Click here to register.

New user training: Large dataset analysis and knowledge base queries using QIAGEN Ingenuity Pathway Analysis (IPA)
2023-03-07 13:00 - 14:30 (America/New_York) | Virtual - Americas - EST, United States
Join us for a 90-minute training session for new users of QIAGEN IPA.
Users will learn how to:
• Upload their dataset (RNA-seq, scRNA-seq, proteomics, metabolomics and more) and perform interactive core/pathway analysis in IPA
• Understand the different result types produced (pathways, key regulators, impact on biological functions/diseases and more)
• Compare different experimental conditions (treatments, timepoints, single-cell clusters, disease types and more) and identify similarities and contrasts
• Generate a network even without a dataset or experimental design for hypothesis generation

Comprehensive Molecular Tumor Analysis with Alacris Theranostics
2023-03-07 11:00 - 12:00 (America/New_York) | Virtual - Americas - EST, United States
Join Dr. Marie-Laure Yaspo, Co-Founder and Chief Scientific Officer of Alacris Theranostics, as she discusses the development, application, and analysis of the Comprehensive Molecular Tumor Analysis (CMTA) test for cancer patients.

Precision oncology approaches have made great strides harnessing individual tumor mutation profiles to guide targeted therapy choices. However, deeper molecular insights are needed to improve personalized treatment decisions. Integrating gene expression analysis in personalized oncology provides an additional level of insight. These analyses include evaluating expressed mutations and drug targets, novel gene fusions, clinically relevant signatures, and the tumor immune microenvironment (TME).
Alacris Theranostics developed the Comprehensive Molecular Tumor Analysis (CMTA), a NGS-based tumor diagnostic test. The test integrates whole exome and transcriptomic sequencing (WES and RNAseq). The test deploys as an end-to-end accredited diagnostic platform from tumor sample uptake (FFPE or frozen) to personalized clinical interpretation reports. CMTA is a tumor-agnostic test that displays a unique molecular view of each sample. CMTA is a useful approach for refractory cancers with complex patterns or tumors of unknown origin.
In this webinar, attendees will:

Learn about the strategy implemented in Alacris’ bioinformatics pipeline to identify cancer-relevant somatic events
Learn how Alacris uses QCI Interpret for Oncology to annotate variants and identify potential therapies
Be eligible for a complimentary QCI Interpret demo and sample report

Drug treatment, toxicology and target safety assessment using QIAGEN IPA and OmicSoft
2023-03-02 13:00 - 14:30 (America/New_York), 2022-05-29 01:00 - 14:30 UTC | Virtual - Americas - EST, United States
In this 90-minute training, you’ll learn how to do drug treatment, toxicology and target safety assessment-related discoveries using QIAGEN Ingenuity Pathway Analysis (IPA) and QIAGEN Omicsoft Lands.
Using public data from GTEx (normal tissue), GEO, cancer collections and more, you’ll learn how to use Omicsoft Lands to:
• Investigate a drug target or biomarker expression across different normal tissues, disease conditions, treatments and more
• Correlate expression of two or more genes
• Identify a list of genes or biomarkers specific to treatment, disease, normal tissue, cell type and more
Using findings from peer-reviewed publications and other sources, attendees we’ll explore with you how to use QIAGEN IPA to:
• Study the impact of targeting a gene/protein on different toxicological and biological functions
• Derive tox findings for a gene of interest from QIAGEN IPA’s knowledgebase
• Identify and study toxicity-related pathways, regulators and functions for an internal dataset or a public dataset
• Compare different drug treatments, other conditions or multi-omics data for novel discoveries
Click here to register.

IPA deeper dive: miRNA investigation using QIAGEN Ingenuity Pathway Analysis (IPA)
2023-02-22 13:00 UTC | Virtual - Americas - EST, United States
In this 90-minute training session, you will learn how to identify target mRNAs for your miRNAs of interest and associate them with pathways, diseases, biological functions, tissues and cell types.
Topics covered:
- How to analyze miRNA-seq datasets alone, or both miRNA and corresponding mRNA datasets together
- How to use QIAGEN IPA without a dataset, using miRNA IDs
- Introduction to databases and curated content specific to miRNA
- How to effectively apply various filters and functionalities to identify biomarkers, key targets and novel biological mechanisms
Click here to register.

QIAGEN IPA deep-dive training, Europe and Middle East
2023-02-17 14:00 - 15:00 UTC | Virtual - EMEA - CET
Join us for a 90-minute training session to learn more about the advanced features of QIAGEN IPA
Users will learn how to:
•Search across over 120,000 analysed public datasets to find analyses of biological interest
•Find experimental conditions that match a user’s data
•Understand how to compare biological signatures and expression patterns of biomarkers across published studies

American Society of Human Genetics (ASHG)
2022-12-15 08:00 - 2022-12-21 17:00 UTC
Forge lasting collaborations, present emerging science, and explore new tools & technologies that will transform your science and accelerate your career growth only at ASHG’s Annual Meeting.

3rd Annual Real-World Data, Life Sciences Analytics and Market Access
2022-11-10 08:00 - 2022-11-25 17:00 UTC
While the 2nd annual Congress had discussions on accelerating the adoption of Real-world Evidence within the industry while understanding the capabilities of newer technologies for evidence generation, the 3rd Annual will focus on how the insights derived from real world data, as well as acknowledgment of the effect the insights can have on improving decision making and patient consideration both internally and by regulators, doctors, and payers.

ACGS Annual Meeting 2021
2022-11-04
The ACGS Organising Committee is looking forward to delivering an exciting programme to showcase the ACGS laboratory diagnostic community. The ACGS encourage participation by trainees and early career investigators from the UK and Ireland.

New user training Europe and Middle East: Large dataset analysis and knowledge base queries using QIAGEN IPA
2022-04-23 02:00 - 15:00 UTC | Virtual - EMEA - CET
Join us for a 60-minute training session for new users of QIAGEN IPA.
Users will learn how to:
• Upload their dataset (RNA-seq, scRNA-seq, proteomics, metabolomics and more) and perform interactive core/pathway analysis in IPA
• Understand the different result types produced (pathways, key regulators, impact on biological functions/diseases and more)
• Compare different experimental conditions (treatments, timepoints, single-cell clusters, disease types and more) and identify similarities and contrasts
• Generate a network even without a dataset or experimental design for hypothesis generation

QIAGEN CLC Main Workbench training
2022-03-30 01:00 - 14:00 UTC | Virtual - Americas - EST, United States
Introduction to QIAGEN CLC Main Workbench
• Alignment and tree construction
• Sanger sequencing analysis
• Cloning and primer design
• Other molecular biology tools
Click here to register.

BioData World Congress 2020
2020-11-13 08:00 - 17:00 UTC
Join QIAGEN Digital Insights Nov. 9–12 for the BioData World Congress 2020 online event, the world's leading congress for big data and artificial intelligence (AI) in life science and healthcare. Explore the QIAGEN Digital Insights virtual booth to discover how our bioinformatics solutions for 'omics data analysis, management and interpretation, as well as tools involving artificial intelligence and machine learning, can transform your research and help you drive discoveries by providing greater efficiency and insights. Join the talk by our expert Jeff Green on Nov. 11 at 9:20 a.m. to learn about Coronavirus Network Explorer, our new web portal with 70 networks depicting how SARS-CoV-2 might affect host cells and tissues. Set up a 1:1 meeting with our experts to explore how QIAGEN Digital Insights can help advance your research.
