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IPA Features

Pattern Search

The Pattern Search feature builds on Analysis Match by enabling you to immediately scan over 100,000 analyses from QIAGEN OmicSoft by querying any collection of genes in a network or pathway. With Pattern Search you can answer questions such as: Which analyses activate this Canonical Pathway through the same genes as in my analysis? Which analyses of diseased tissue are the “opposite” of the gene signature for my drug, and may benefit from treatment with the drug? Do any analyses have an interaction network or Regulator Effects network similar to the one in my analysis? Start with any network or pathway from an analysis, or simply place genes of interest into a new My Pathway, then either overlay a dataset or manually color the genes with the MAP paint bucket to “activate” or “inhibit” them. Click the “Pattern Search” button to discover which OmicSoft analyses have similar or different gene expression patterns. Please note that the Pattern Search feature is included with Analysis Match or Match Explorer licenses in IPA.

Graphical Summary

Graphical Summary provides you with a quick overview of the major biological themes in your IPA Core Analysis and illustrates how these concepts relate to one another. This feature selects and connects a subset of the most significant entities predicted in the analysis, creating a coherent and comprehensible synopsis of the analysis. The Graphical Summary can include entities such as canonical pathways, upstream regulators, diseases and biological functions. The algorithm constructs the summary using machine learning techniques to prioritize and connect entities and infers relationships to connect entities not yet connected by findings in the QIAGEN Knowledge Graph. These inferred relationships help you visualize related biological activities.

Activity Plot

Visualize and explore the activity of a single QIAGEN IPA entity, such as an Upstream Regulator, Causal Network, Canonical Pathway, Disease or Function, across >100,000 OmicSoft Land analyses. The Activity Plot helps you gain insights into an IPA entity by exploring its predicted biological activity across thousands of datasets that represent disease conditions, treatment conditions, knockouts and much more in the Analysis Match database. Please note that the Activity Plot feature is included with Analysis Match or Match Explorer licenses in IPA.

Analysis Match

Broaden the scope of your discovery when you evaluate your dataset in the context of over 100,000 IPA analyses.

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Land Explorer

Interactively explore the data details underlying Analysis Match with QIAGEN Land Explorer. Over 600,000 disease-relevant samples are available from published omics studies from human, mouse and rat, covering multi-omics data from hundreds of diseases. Visualize data with expression, mutation, copy number, and more to broaden your understanding of how changes in genes lead to common diseases. Data visualizations can be filtered and grouped on thousands of curated metadata fields to reveal patterns. Please note that the QIAGEN Land Explorer features is included with Match Explorer licenses in IPA.

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Path Designer

Transform your networks and pathways in QIAGEN IPA into publication-quality pathway graphics rich with color, customized text and fonts, biological icons, organelles, and custom backgrounds. Expand and explore pathways using the high quality content stored in QIAGEN IPA.

Phosphorylation Analysis

Changes in the phosphorylation states of proteins provide an important regulatory mechanism in mammalian cells. Discover upstream regulators and causal network master regulators that may be driving the changes in phosphorylation levels of the proteins in your phosphoproteomics dataset. Visualize how the phosphorylated proteins affect Canonical Signaling pathways. These results provide testable hypotheses by identifying potential signaling cascades from the phosphorylation patterns in your dataset.

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IsoProfiler helps you to identify and prioritize isoforms having interesting biological properties relevant to your research. Find genes with RNA transcripts having unusual pattern(s) of expression such as isoform switching or with known diseases or functions. Or use the fully integrated human GTEx expression data to identify transcripts with known tissue-specific expression. Visualize isoform-level expression in one or across multiple datasets.

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Causal Network Analysis

Generates multi-leveled regulatory networks that may explain the gene expression changes exhibited in a dataset. It enables the discovery of novel regulatory mechanisms by expanding upstream analysis to include regulators that are not directly connected to targets in the dataset.

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BioProfiler searches the QIAGEN IPA Knowledge Base of scientific information to generate molecular profiles of diseases, phenotypes, and biological processes (e.g., apoptosis) listing all the genes and compounds that have been associated with the profiled term. Find, filter, and prioritize genes and compounds based on the research question at hand. Focus on molecules of interest, find causally relevant genes, filter for specific genetic evidence or for species, and explore associations with similar diseases or phenotypes. The surfaced data can then be examined further in the context of pathways using all available QIAGEN IPA features.

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Regulator Effects

Provides insights into your data by integrating Upstream Regulator results with Downstream Effects results to create causal hypotheses that explain what may be occurring upstream to cause particular phenotypic or functional outcomes downstream.

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Biomarker Filter

Rapidly identify the best biomarker candidates based on biological characteristics most relevant to the discovery study.

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Gene and ChemView

QIAGEN IPA's Search & Explore capabilities offer researchers access to the most current Findings available on genes, drugs, chemicals, protein families, normal cellular and disease processes, and signaling and metabolic pathways.

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Comparison Analysis

Quickly visualize trends and similarities across analyses using heat maps for Canonical Pathway, Downstream Effects, Upstream regulators and Causal Network Analyses. Prioritize by score, hierarchical cluster or trend.

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Mechanistic Networks

Automatically generate plausible signaling cascades describing potential mechanism of action leading to observed gene expression changes.

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Downstream Effects Analysis

Identify whether significant downstream biological processes are increased or decreased based on gene expression results.

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Molecule Activity Predictor (MAP)

Interrogate sub-networks and Canonical Pathways and generate hypotheses by selecting a molecule of interest, indicating up or down regulation, and simulating directional consequences of downstream molecules and the inferred activity upstream in the network or pathway.

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Canonical Pathway

Pathway Analysis, Canonical Pathways, Overlapping Pathways, Pathway Import and scoring. Determine most significantly affected pathways. Analyze your data in the context of established signaling and metabolic pathways. Determine the most significantly affected pathways and those that are predicted to be activated or inhibited. Determine which pathways overlap based on molecules in common.

Tox Lists and Tox Functions

IPA-Tox uses Toxicity Functions in combination with Toxicity Lists to link experimental data to clinical pathology endpoints, understand pharmacological response, and support mechanism of action and mechanism of toxicity hypothesis generation.

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Disease View

Provides details associated with the disease or biological function such as molecules associated with that disease or function, known drug targets, drugs known to target those molecules, and more.

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Upstream Regulator Analysis

Predict upstream molecules, including microRNA and transcription factors, which may be causing the observed gene expression changes.

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Isoform View

Understand the structure and function of both human and mouse isoforms (splice variants). For each gene, toggle between human or mouse RefSeq and Ensembl to visualize associated isoforms on the Isoform View.

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Interaction Network Analysis

Build and explore transcriptional networks, microRNA-mRNA target networks, phosphorylation cascades and Protein-Protein or Protein-DNA interaction networks. Identify regulatory events that lead from signaling events to transcriptional effects. Understand toxicity responses by exploring connections between drugs or targets and related genes or chemicals. Edit and expand networks based on the molecular relationships most relevant to the project.

MicroRNA Target Filter

Reduce the number of steps it takes to confidently, quickly, and easily identify mRNA targets by letting you examine microRNA-mRNA pairings, explore the related biological context, and filter based on relevant biological information as well as the expression information. The microRNA Target Filter in IPA provides insights into the biological effects of microRNAs, using experimentally validated interactions from TarBase and miRecords, as well as predicted microRNA-mRNA interactions from TargetScan. Additionally, IPA includes a large number of microRNA-related findings from the peer-reviewed literature.

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